In this system, we used DNA oligonucleotides as a backbone to synthesize a nanostructure with silver nanoclusters in the head and functional fragments in the tail, which is shaped like a sperm, to achieve dual functions of ultrafast delivery and imaging/therapy. As a model, we analyzed the possibility of the “nano-sperm” carrying DNA with
Popular answers (1) The simple way I try to remember this is to always design my sequence so that the 3' end is directly before the NGG. So if my sequence is on the antisense strand and the sense
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Аσуնаξи уքофኡв
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Antisense oligonucleotides (ASOs) have been validated as therapeutic agents and an important tool in molecular biology. Indeed, ASOs are used either in vitro or in vivo to generate mRNA selective knockouts. They can be used for human therapy since ASOs can inhibit specifically target genes especially whose are difficult to target with small molecules inhibitors or neutralizing antibodies an·ti·sense DNA. the strand of DNA complementary to the one bearing the genetic message and from which it may be reconstructed; a DNA sequence complementary to a portion of mRNA; used as potential therapeutic agent to stop transcription or translation of pathogens or inappropriately expressed host gene. Farlex Partner Medical Dictionary
Ionis’ antisense technology. With RNA as the target that forms the basis of our novel drug discovery platform, we are tackling the most difficult to treat diseases with a focus on neurology and cardiometabolic diseases. Our antisense therapies are disrupting diseases and, we hope, changing their course—from the rarest of conditions, to
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